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Rapid Fire and Poster Presentations

Wednesday, Sept. 20, 2023

3–3:20 p.m.—Rapid Fire Oral Session 1

View Rapid Fire Oral Session 1 Abstracts

1. 3–3:05 p.m. | Ioannis Baltas
   Exploring the Views of Infection Consultants in England on a Novel Delinked Funding Model for Antimicrobials: the SMASH study.


2. 3:05–3:10 p.m. | Nicola Farrington
   Development of a Rabbit Model of Nosocomial Pneumonia to Combat Emergence of Resistance.


3. 3:10–3:15 p.m. | Blanca Fernandez
   Novel Inhibitors of the Two-Component System VanRS Re-sensitize Enterococcus Faecalis to Vancomycin.


4. 3:15–3:20 p.m. | Cecilia Gutierrez Perez
   Targeting Aspergillus fumigatus Hypoxia Response Pathways for Novel Antifungal Drug Development.

3:30–4:15 p.m.—Posters Presentations Session 1

View Posters Presentations Session 1 Abstracts

• Mark Pulse | Epidemic Clostridioides difficile Isolates are Significantly More Lethal and Persist at Higher Rates than Non-Epidemic Isolates in Hamsters Following Vancomycin Treatment.
  Poster #001


• Vidmantas Petraitis | Development of Rabbit Models of Ventilator-Associated Carbapenem-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii Pneumonia.
  Poster #002


• Povilas Kavaliauskas | Exploring Potential MCR-1 Inhibitors: Restoring In Vitro Polymyxin Activity in MCR-1-Producing Enterobacteriales.
  Poster #003


• Shakeel Ahmad | Exploring the Effect of Sub-MIC Antibiotic Exposure on Bacterial Hetero-resistance at Single Cell Level.
  Poster #004


• Syed Ahmed | Recombinant Phage-encoded Lysin Exhibits Antibacterial Activity Against Drug-Resistant Uropathogenic Escherichia coli.
  Poster #005


• Jane Ambler | Exebacase MIC Determination for Staphylococci Other Than Staphylococcus aureus (SoSA).
  Poster #006


• Jane Ambler | Method Verification of Exebacase MIC Method for Staphylococci Other Than S. aureus (SoSA).
  Poster #007


• Venkataraman Balasubramanian | Oral Pharmacokinetics and Efficacy of BWC0977, a Novel Bacterial Topoisomerase Inhibitor.
  Poster #008


• Soumya Biswas | Biochemical and Biophysical Characterization of Klebsiella pneumoniae FabI, a Target for Antibacterial Drug Discovery.
  Poster #009


• Vinolia Chellaraj | A Randomized, Double-Blind, Placebo Controlled Multicenter Study to Evaluate the Efficacy and Safety of CAL02 Administered Intravenously in Addition to Standard of Care in Subjects With Severe Community Acquired Bacterial Pneumonia (SCABP).
  Poster #010


• Danielle Domo | Surveillance of the Impact of Antimicrobial Resistant Infections in Immunocompromised Children: A Systematic Review.
  Poster #011


• Vineet Dubey | Dynamic Interplay of MexAB-OprM, PDC-5 and OprD in Pseudomonas aeruginosa Facilitates Emergence of Meropenem Resistant Phenotype in Rabbit Pneumonia Model.
  Poster #012


• Nicola Farrington | Murine Pharmacodynamics of Oral Avibactam Pro-Drug in Combination With Ceftibuten.
  Poster #013


• Diane Flayhart | Burden of Antimicrobial Resistance in Hospitalized Patients with Cancer: A Multicenter Analysis.
  Poster #014


• Rajashree Gandge | Evaluation of Antibacterial Activity of Oxytetracycline Hydrochloride Loaded Nanoparticulate Drug Delivery System against Brucella abortus.
  Poster #015


• Susan Gardlik | A Novel Fosfomycin-Trimethoprim-Sulfamethoxazole Combination Exhibits Marked In Vitro Antibacterial Synergy Against Bacteria Causative of Urinary Tract Infections.
  Poster #016


• Haleigh Gilliland | A Genome Wide Screen Defines Macrophage Genes Modulating Intracellular Control of Mycobacterium abscessus Following Antibiotic Treatment.
  Poster #017


• Getahun Tadesse Gurmessa | Exploring Secondary Metabolites to Combat Multidrug-Resistant Pathogens From Ethiopia Plants.
  Poster #018


• Theresa Hartsell | In-vitro Antibacterial Activity of a Fosfomycin-Trimethoprim-Sulfamethoxazole Combination Against a Bacterial Collection of Multidrug-Resistant Clinical Isolates.
  Poster #019


• Tesleem Ibrahim | Antibacterial Activity of Medicinal Plant Infusions and their Combination With Antibiotics Against Salmonella enterica and Escherichia coli.
  Poster #020


• Niilo Kaldalu | Repurposing of Drugs to Fight Persistent Infections—Antibacterial Compounds Against Non-growing Bacteria.
  Poster #021


• Davinder Kaur | Establishment of Loop Mediated Isothermal Amplification Assay for the Surveillance of Multi-drug Resistance Markers in P.vivax Clinical Isolates and Chloroquine Transporter Markers in P.falciparum Clinical Isolates.
  Poster #022


• Maria Khan | A Parallel Threat of Extensively Drug-Resistant Typhoid Fever in Pediatric Cohort During COVID-19 Pandemic.
  Poster #023


• Andreas Klein | LasB Inhibitor Characterization by Novel Lung Homogenate-Based Assays.
  Poster #024


• Alex Lepak | Pharmacodynamic Evaluation of MK-3402 in Murine Thigh and Lung Infection Models against Pseudomonas aeruginosa Strains With Metallo-β-lactamases.
  Poster #025


• Eldeen Lim | Rational Design of Membrane Active Antimicrobials Against Multi-drug Resistant Gram-Negative Bacteria.
  Poster #026


• Zaika Stepanskyi | Antimicrobial Effect of N-Chlorotaurine on Resistant Isolates Obtained from Combat-Related Extremity Wounds.
  Poster #027


• Sudeshna Roy | Unlocking the Potential of 1,2,4-Triazolyl Derivatives as a New Treatment for Tuberculosis.
  Poster #028

Thursday, Sept. 21, 2023

11–11:20 a.m.—Rapid Fire Oral Session 2

View Rapid Fire Oral Session 2 Abstracts

1. 11–11:05 p.m. | Jennifer Jones
   The Urinary Microbiome as a Source of Novel Antimicrobials Against Uropathogenic Escherichia coli.


2. 11:05–11:10 p.m. | Cong Ma
   Targeting Protein-Protein Interactions for Novel Antibiotic Discovery.


3. 11:10–11:15 p.m. | Derry Mercer
   HoloMoA: Digital Inline Holographic Microscopy to Rapidly and Cost-effectively Determine the Mechanism of Action (MoA) of Antimicrobials.


4. 11:15–11:20 p.m. | Carsten Seyfert
   Optimization of Darobactins Improving the Antibiotic Activity by Structure and Activity Guided Biosynthetic Engineering.

11:30–12:15 p.m. – Posters Presentations Session 2

View Posters Presentations Session 2 Abstracts

• Carina Lundberg | Evaluation of a Standard Protocol for the Murine Pneumonia Model to Investigate Antibiotic Treatment Effect of Infections With MDR Gram-Negative Bacteria.
  Poster #001


• Alasdair MacGowan | Effect of Media on the Bactericidal Activity of NOSO502, a Novel Odilorhabin Antibiotic.
  Poster #002


• Satwik Majumder | Nanocomposite of Halloysite Clay, Nano-silver, and Tannic Acid as a Therapy to Combat Multi-drug Resistant Salmonella typhimurium in a Caenorhabditis elegans Model of Intestinal Infection.
  Poster #003


• Hilario Mantovani | Efficacy of an AMP-Based Therapy to Control Bovine Mastitis Pathogens.
  Poster #004.


• Hilario Mantovani | Synergistic Bactericidal Activity of Bovicin HC5 in Combination With Cephalosporins Against Bovine Mastitis Pathogens and MRSA.
  Poster #005


• Nhlayiso Atalia Maswanganyi | Diagnostic Accuracy of Rapid Assays For Diagnosis of Bloodstream Infections And Antimicrobial Profiling of Pathogens That Causes Bloodstream Infections At a Tertiary Hospital In Polokwane, Limpopo Province, South Africa (SoSA).
  Poster #006


• Carina Matias | Time-Kill Kinetics of the Novel Broad Spectrum β-lactamase Inhibitor APC247.
  Poster #007


• Laura McEntee | Murine Pharmacodynamics of SPR206.
  Poster #008


• Laura McEntee | Pharmacokinetics-Pharmacodynamics (PK-PD) of New Broad-Spectrum Agent BWC0977.
  Poster #009


• Hannah Meredith | Predicting Efficacious Exposures for a Novel β-lactam/β-lactamase Inhibitor With a Semi-mechanistic Model.
  Poster #010


• Greg Moeck | Susceptibility Profiles of Baseline Gram-Negative Pathogens from CERTAIN-1, a Phase 3 Study Comparing Cefepime-taniborbactam to Meropenem in Adults With Complicated Urinary Tract Infection (cUTI).
  Poster #011


• Monica Murphy | Investigating the Ability of Saltwater Isolates to Inhibit Biofilm Formation by Clinically Significant Pathogens.
  Poster #012


• Ai Muto | Observations of Bacterial Persister Population Dynamics in Antibiotic Environments Using a Library of Escherichia coli Gene Deletion Strains.
  Poster #013


• Ayodeji Osunla | Studies on Proximate Analysis and Biocidal Potentials of Extracts from Hibiscus sabdariffa Calyx on Bacterial Strains Associated with Human Infections.
  Poster #014


• Marco Gontijo | Susceptibility of the Anaerobes Bacteroides spp., Clostridium spp., and Clostridioides difficile to a Unique Synergistic Antibacterial Combination.
  Poster #015


• John Pace | A Novel Fosfomycin-Trimethoprim-Sulfamethoxazole Combination Exhibits Marked In Vitro Antibacterial Synergy Against Bacteria Causative of Urinary Tract Infections.
  Poster #016


• Paola San Martin Galindo | Efficacy of Multisubstituted Pyrimidines on Single- and Dual-Species Staphylococcus aureus and Pseudomonas aeruginosa Biofilms.
  Poster #018


• Taila Solomon | Extracellular Vesicles Exhibit Antibiofilm Effects on Pseudomonas aeruginosa.
  Poster #019


• Chad Testa | CZ-02s are a New Class of Antibiotics, With a New Mechanism-of-Action to Treat Multidrug-Resistant Bacteria.
  Poster #020


• Shabnam Thakur | Antibacterial and Antioxidant Activities of Chlorophytum borivilianum Extract Mediated Synthesized Silver Nanoparticles.
  Poster #021


• Xiao Yang | Discovery and Development of Novel Inhibitors for Bacterial Ribosomal RNA Synthesis as First-In-Class Antimicrobial Candidates.
  Poster #022


• Matej Zore | Etrasimod and its Derivatives as Antibacterial Agents Against Gram-Positive Bacteria.
  Poster #023


• Piotr Garstecki | Microfluidic System for Massively Parallel Antimicrobial Susceptibility Testing and Detection of Resistance Mechanisms.
  Poster #024


• Andreas Kany | Optimization of Pseudomonas aeruginosa LasB Inhibitors Guided by In Vitro ADMET Profiling.
  Poster #025


• Chen Situ | Antibacterial Potency of Medicinal Plants Against Methicillin-Resistant Staphylococcus aureus.
  Poster #026