2024 was a very active year on research in antimicrobial resistance, highlighted by an impactful and high level political declaration to combat antimicrobial resistance by the °®¶¹´«Ã½ Nations. In this episode, trainees from NIH-funded training program (T32) on antimicrobial resistance discuss the most relevant research on the field in the year 2024.
Topics discussed:
- The best papers of 2024 in gram-positive, gram-negative, mycobacterial and parasite resistance
Guests:
- Nathalie Chen: University of Pittsburgh, Pittsburgh, PA
- Alex Kang: Houston Methodist Research Institute, Houston, TX
- Nathan Raabe: University of Pittsburgh, Pittsburgh, PA
- Taylor Blackburn: Emory University, Atlanta, GA
- Jacon McPherson: University of Houston, Houston, TX.
- Lee Harrison, M.D.: Associate Chief of Epidemiology and Microbial Genomics, Professor of Medicine and Epidemiology, Director, Center for Genomic Epidemiology, Director, T32 AMR, U of Pittsburgh
- William Shafer, Ph.D.: Professor, Department of °®¶¹´«Ã½ and Immunology, Emory University School of Medicine, Co-Director, Emory Antibiotic Resistance Center. Director T32 AMR, Emory University
Links:
Taylor Blackburn- In vitro efficacy of next-generation dihydrotriazines andbiguanides against babesiosis and malaria parasites DOI
- Inhibition of AMPK activation in Echinococcus granulosus sensustricto limits the parasite’s glucose metabolism and survival DOI
- Li S, Tyagi S, Soni H, Betoudji F, Converse PJ, Mdluli K, Upton AM, Fotouhi N, Barros-Aguirre D, Ballell L, Jimenez-Navarro E, Nuermberger EL.2024.Bactericidal and sterilizing activity of novel regimens combining bedaquiline or TBAJ-587 with GSK2556286 and TBA-7371 in a mouse model of tuberculosis. Antimicrob Agents Chemother68:e01562-23.
- Le Run E, Tettelin H, Holland SM, Zelazny AM.2024.Evolution toward extremely high imipenem resistance in Mycobacterium abscessus outbreak strains. Antimicrob Agents Chemother68:e00673-24.
- Molecular physiological characterization of the dynamics of persister formation in Staphylococcus aureus
- Bacteriophage therapy reduces Staphylococcus aureus in a porcine and human ex vivo burn wound infection model
- Relative inhibitory activities of the broad-spectrum beta-lactamase inhibitor xeruborbactam in comparison with taniborbactam against metallo-beta-lactamases produced in Escherichia coli and Pseudomonas aeruginosa (Le Terrier et al)
- Inhibition of Pseudomonas aeruginosa quorum sensing by chemical induction of the MexEF_oprN efflux pump (Kristensen et al)
- Precise genome editing underlines the distinct contributions of mutations in ERG11, ERG3, MRR1, and TAC1 genes to antifungal resistance in Candida parapsilosis
- Exploration of novel mechanisms of azole resistance in Candida auris
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